7 Signs of Gamma Linolenic Acid Deficiency

You probably haven't heard much about gamma linolenic acid (GLA) deficiency, but it's a super common fatty acid deficiency (I find it in about 90% of my clients) that has huge ramifications on your cellular health and inflammation status. When it comes up in mainstream news, it's typically being touted for its skin, hair and nail perks.

Deficiency

Common signs of GLA deficiency can be vague, but include:

inflammation
dry hair
skin issues
bumps on the back of your arms
cracked fingertips
unwanted gene expression
increased body fat

GLA Status Determinants

GLA is a potent anti-inflammatory omega-6 fatty acid that is synthesized in the body from linolenic acid (LA). Linolenic acid is found abundantly in omega-6 fatty acids like safflower, sunflower, sesame, corn, and cottonseed oils, which there is no shortage of in the standard American diet.

If the precursor to GLA is abundant in most people's diet, why is GLA deficiency so rampant?

It all comes down to conversion modulators as well as your general health.

You see, there are certain modulators that support the conversion of LA into GLA via the enzyme delta-6-desaturase. These include:

Zinc
B6
B3
Magnesium
Vitamin C
Vitamin E

If your body's deficient in some of these, your GLA conversion status will likely be impaired.

And then there are also modulators that block or reduce the conversion of LA into GLA. They include:

Age
Insulin
Coffee
Alcohol
Trans fats

So as you can see, improving your GLA status naturally requires a full body nutrition approach, although there are also shortcuts...

Sources of Preformed GLA

The biggest shortcut to skipping any conversion issues (which should be addressed as well) is taking preformed GLA.

Sources of preformed GLA include [1,2,3,4]:

leafy greens
hempseed
oats
spirulina
breastmilk (source for infants)
borage oil (20-27% GLA)
evening primrose oil (7-14% GLA)
black current seed oil (15-20% GLA)

Benefits

The perks of GLA sufficiency are abundant, so take note below of what optimizing your levels could mean for you:

GLA can have the following impact:

Anti-inflammatory, antithrombotic, antiproliferative (inhibit cell growth in tumor cells), lipid-lowering potential: "GLA, via conversion to PGE1, exhibits anti-inflammatory, antithrombotic, antiproliferative, and lipid-lowering potential. It also enhances smooth muscle relaxation and vasodilation. In addition, EFAs including GLA are important constituents of membrane phospholipids, including the mitochondrial membrane, where they enhance the integrity and the fluidity of the membrane" [1]
Body fat mass reduction: A study from 2000 linked GLA to reducing body fat accumulation. "It was suggested that dietary gamma-linolenic acid attenuates body fat accumulation through the increase in gene expressions of uncoupling protein 1 in brown adipose tissue. An increase in hepatic peroxisomal fatty acid oxidation may also contribute to the physiological activity of gamma-linolenic acid in decreasing body fat mass." [3]

GLA has also been studied for a number of clinical applications with promising outcomes for: [1]

Rheumatoid Arthritis
Atopic Eczema
Cardiovascular Disease
Asthma
Premenstrual Syndrome
Attention Deficit/Hyperactivity Disorder
Cancer
Dry Eye Syndrome
Osteoporosis

Testing

My favorite test for GLA is a simple at home blood-spot collection kit. After collecting a small drop of blood on a sample card, you pop your sample in the mail and get your results emailed in approximately one week. I also created a 30 minute video training you can watch to help you understand your results and what you can do about it.

I typically test myself every 6 months or so to make sure I'm keeping my fatty acid balance in check to combat cellular inflammation.

Find the simple at-home test kit here.

A Sane Nutrition Approach

My approach to nutrition is pretty simple — make sure your body has all the raw materials it needs (and the right environment) to support your body's natural desire for health.

Give your body what it needs (based on testing), and then get out of the way.

Live your life without stressing about it.

If you need help, you can find it here.

PIN IT:

References:

https://altmedrev.com/wp-content/uploads/2019/02/v9-1-70.pdf
https://pubmed.ncbi.nlm.nih.gov/17168669/
https://pubmed.ncbi.nlm.nih.gov/11079375/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768453/
https://www.researchgate.net/publication/319099698_Spirulina_A_source_of_gamma-linoleic_acid_and_its_applications